منابع مشابه
Hepatosplenic candidiasis--a contraindication to marrow transplantation?
To determine whether a prior history of hepatosplenic candidiasis resulted in increased Candida-associated morbidity and mortality after marrow transplant, 15 consecutive patients with biopsy-proven hepatosplenic candidiasis were observed prospectively. All patients received amphotericin B before transplant. Amphotericin B was continued at a dose of 0.5 mg/kg/day from conditioning through marro...
متن کاملHepatosplenic candidiasis: successful treatment with fluconazole.
PURPOSE To determine if fluconazole is effective treatment for hepatosplenic candidiasis that has not resolved with amphotericin B and flucytosine treatment. PATIENTS AND METHODS Six patients (ages 3 to 44) with acute leukemia and hepatosplenic candidiasis who did not respond to prior antifungal therapy were treated with fluconazole. RESULTS All six patients had fever and three had nausea a...
متن کاملHepatosplenic candidiasis in patients with acute leukaemia.
A retrospective study of 23 patients with acute leukaemia and hepatosplenic candidiasis (HSC) was conducted to evaluate clinical treatment characteristics in terms of amount and duration of antifungal agents and to assess treatment outcome. Patients were admitted to two major tertiary care centres between 1990 and 1998. The diagnosis of HSC was based on clinical, blood cultures, histologic and ...
متن کاملHepatosplenic candidiasis complicating acute myeloid leukaemia.
A 33-year-old man with acute myeloid leukaemia developed neutropenic fever after induction chemotherapy with cytarabine and daunorubicin. The first blood culture was positive for Escherichia coli and the patient was treated with imipenem (500 mg every 6 hours intravenously [IV]). However, the fever persisted and liver function tests were deranged; alkaline phosphatase (ALP) was 166 U/L (referen...
متن کاملHepatosplenic Candidiasis Detected by 18F-FDG-PET/CT
Hepatosplenic candidiasis is a fungal infection, which mostly affects patientswith hematologic malignancies such as leukemia. The pathogenesis of thisinfection is not clear yet, and the liver is the most commonly affected organ.Diagnosis of hepatosplenic candidiasis can be only established via biopsy,since computed tomography (CT) scan, ultrasonography, and magneticresonance imaging (MRI) yield...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2007
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmicm040112